Clomid anabolic effects  Clomid is the commonly referenced brand name for clomiphene citrate . The substance is not an anabolic steroid , but Clomid generally prescribed to women as a fertility aid . This is due to the fact that clomiphene citrate shows a pronounced ability to stimulate ovulation . This is accomplished by blocking/minimizing the effects of estrogen in the body. To be more specific Clomid is chemically a synthetic estrogen with both agonist/antagonist properties, and is very similar in structure and action. In certain target tissues it can block the ability of estrogen to bind with its corresponding receptor. Clomid's clinical use is therefore to oppose the negative feedback of estrogens on the hypothalamic-pituitary-ovarian axis, which enhances the release of LH and FSH. This of course can help to induce ovulation .
Clomid and effects of estrogen
Offers dual effect of blocking out some of the effects of estrogen , while also increasing endogenous testosterone production . Clomid is the anti-estrogen of choice for improving recovery of natural testosterone production after a cycle , improving testosterone production of endurance athletes, and this drug is also effective in reducing risk of gynecomastia during a cycle employing aromatizable steroids. While it has been claimed that Clomid "stimulates" production of LH and therefore of testosterone, in fact Clomid's activity is achieved not by stimulation of the hypothalamus and pituitary, but by blocking their inhibition by estrogen.
Clomid is a mixed estrogen
Clomid is a mixed estrogen agonist/antagonist (activator/blocker) which, when bound to the estrogen receptor , puts this product in a somewhat different conformation (shape) than does estradiol. The estrogen receptor requires binding of an estrogen or drug at its binding site and also the binding of any of several cofactors at different sites. Without the binding of the cofactor, the estrogen receptor is inactive. Different tissues use different cofactors. Some of these cofactors are able to bind to the estrogen receptor/Clomid complex, but others are blocked due to the change in shape. The result is that in some tissues Clomid acts as an antagonist -- the cofactor used in that tissue cannot bind and so the receptor remains inactive -- and in others its acts as an agonist (activator), because the cofactors used in that tissue are able to bind. Clomid is an effective antagonist in the hypothalamus and in breast tissue. It is an effective agonist in bone tissue, and for improving blood cholesterol.
Clomid adverse effect
Clomid also has the property of reducing the adverse effect of exercise-induced damage of muscle tissue . This is very significant for endurance athletes but is not very significant, if at all significant, with reasonable weight training . Clomid does not perceptibly affect gains of the weight trainer either favorably or adversely in my experience. Clomid seems to have estrogenic effects on mood, which can be beneficial (improving relationships with women by improving empathy) or can yield depression or PMS-like symptoms, but for most users there is no significant effect either way. The claim that duration of intake should not exceed 10-14 days is incorrect. Clinical studies with male patients have been for periods of a year or longer. This error probably originates from the fact that, for use in women, due to the menstrual cycle there would obviously be no point in trying to stimulate ovulation all four weeks of the month. Thus, use in women is limited to 10-14 days. That limitation is not because of toxicity. Clomid is in fact useful throughout a cycle if aromatizable drugs are being used . I do think however that to be conservative, one should use it no more than 2/3 of the time throughout the year or a little less.
Clomid for athletic purposes
For athletic purposes, Clomid does not offer a tremendous benefit to women. In men however, the elevation in both follicle stimulating hormone and (primarily) luteinizing hormone will cause natural testosterone production to increase. This Clomid effect is especially beneficial to the athlete at the conclusion of a steroid cycle when endogenous testosterone levels are depressed. If endogenous testosterone levels are not brought beck to normal, a dramatic loss in size and strength is likely to occur once the anabolics have been removed. This is due to the fact that without testosterone (or other androgens), the catabolic hormone cortisol becomes the dominant force affecting muscle protein synthesis (quickly bringing about a catabolic metabolism).
Clomid role in the post-steroid crash
Often referred to as the post-steroid crash , it can quickly eat up much of your newly acquired muscle. Clomid® can play a crucial role in preventing this crash in athletic performance. As for women, the only real use for Clomid® is the possible management of endogenous estrogen levels near contest time. This can increase fat loss and muscularity, particularly in female trouble areas such as this hips and thighs. Clomid® however often produces troubling side effects in women, and is likewise not in very high demand among this group of athletes.
Combination of Clomid and HCG
 Male users generally find that a daily intake of 50-100 mg (1-2 Clomid tablets ) over a four to six weeks period will bring testosterone production back to an acceptable level. This raise in testosterone should occur slowly but evenly throughout the period of intake. Since an immediate boost in testosterone is often desirable, many prefer to combine Clomid with HCG (Human Chorionic Gonadotropin) for the first week or two after the steroids have been removed. The kick-start from HCG also helps to restore the normal ability for the testes to respond to endogenous LH, which may be hindered for some time after the cycle is ended due to a prolonged state of inactivity. Once the HCG is stopped, the user continues treatment with Clomid alone. HCG should not be used for longer than two or three weeks though, as the resulting increased testosterone and estrogen levels may again initiate negative feedback inhibition at the hypothalamus. When planning your ancillary drug program, it is also important to remember that injectable steroids can stay active for a long duration. Using ancillary drugs the first week after a long acting injectable like Sustanon has been stopped may prove to be wholly ineffective. Instead, the athlete should wait for two to three weeks, to a point where androgen levels will be diminishing. Here the body will be primed and ready to restore testosterone production.
Clomid and HCG steroid cycle
Clomid and HCG are also occasionally used periodically during a steroid cycle , in an effort to prevent natural testosterone levels from diminishing. In many instances this practice can prove difficult however, especially when using strong androgens for longer periods of time. There is also no exact method for using the two drugs in this manner. Some have experimented by periodically administering small doses of HCG along with one or two tablets of Clomid, perhaps for a few days at a stretch followed by a longer break. An on/off schedule would be implemented; for fear that this combination may lose some effectiveness if used continuously for this purpose. This method of intake may prove to be effective, although it is really much more feasible to stimulate testosterone production after the cycle than to try and maintain it for the long duration during.
Clomid steroid cycle
In addition to helping with the post-cycle testosterone crash, Clomid can also help with elevated estrogen levels during a steroid cycle. A high estrogen bevel puts an athlete in serious risk of developing gynecomastia, which is an obvious unwanted side effect. With the intake of Clomid, the athlete can hopefully reduce Clomid risk for developing gynecomastia . The estrogen "blocking" properties of Clomid appear to be slightly weaker than Nolvadex in comparison however, which is why it is not usually thought of as an equal substitute for estrogen maintenance. Of course both drugs have similar actions in the body. and are relatively interchangeable for this purpose. Clomid can likewise also be used as a maintenance anti-estrogen throughout the duration of steroid intake with good confidence, just as is done with Novadex. In most instances this will prove equally sufficient, the drug effectively minimizing the activity of estrogen in the body and warding off gyno and excess water/fat retention. Unfortunately just as with Nolvadex this is not always the case however, and many find it necessary to addition another antiestrogenic drug. The most common adjunct is Proviron®, an oral DHT used to competitively lower aromatase activity and raise the androgen to estrogen ratio. The Clomid and Proviron combination is extremely effective, although we could alternately .eplace them both with a more specific aromatase inhibitor such as Arimidex or Cytadren . While stronger at combating estrogen in most cases, these drugs are also typically much more costly.
Clomid side effects
As for toxicity and side effects, Clomid is considered a very safe drug . Bodybuilders seldom report any problems with Clomid, but listed possible side effects of Clomid do include hot flashes, nausea, dizziness, headaches and temporarily blurred vision. Such Clomid side effects usually only appear in females however, as they feel the effects of estrogen manipulation much more readily than men. While female athletes can clearly gain some benefit from this substance, estrogen manipulation is probably not the most comfortable way to go about cutting up. Should it still be used for such purposed and side effects do become pronounced, Clomid of course is to be discontinued and (at least) a break taken from it. [ BUY ANTI ESTROGEN DRUGS ]
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